Let's Talk Nixodine™
What is Nixodine™?
Simply put, Nixodine™ is what make SHGR Snuff what it is. It's a revolutionary analog, a non-nicotine ingredient that mimics nicotine and delivers that satisfying feeling of focus and energy you're looking for, without any of the tobacco or nicotine.
What is the advantage of Nixodine™?
All the Feel-Good, None of the Guilt: Get that buzz you want with zero nicotine and zero tobacco.
Clean Energy & Focus: Perfect for work, gaming, or just getting through the day.
Tested and Trusted: We've done the work in the lab and with independent testing. Nixodine™ is rigorously tested to be non-carcinogenic and non-mutagenic. It has also shown to be slightly less addictive than nicotine (a6 interaction below).
Nixodine™ has gone through rigorous testing over the last two years, with even more studies planned for the near future. We have performed toxicity studies in vitro and in vivo to confirm that Nixodine™ is not carcinogenic, nor mutagenic, and has a similar toxicity profile to that of nicotine.
We have also performed ‘receptor-binding affinity’ studies to measure how exactly Nixodine™ interacts with nAChRs. These studies show that, in aggregate, Nixodine™ has an extremely similar binding affinity to that of nicotine in the α3 AChR (pronounced ‘Alpha 3’) and α4 AChR nicotinic receptors (think the excitement and "highs" from using nicotine) but interestingly, binds less effectively to the α6 AChR. This specific receptor plays a signifcant role in nicotine dependence.
Simply put, Nixodine™ gives you that same satisfaction with much lower tendency toward addiction.
Quality You Can Count On: Made right here in the USA with natural, plant-based, and food-grade ingredients.
Nixodine™ is produced through a proprietary process of modifications to nicotinic acids (B-vitamins). It is produced in a FDA-registered facility in the United States. This facility is CGMP, and ISO-9001 certified. There are zero tobacco products or derivatives involved in this process.
How was Nixodine™ developed?
Let's step back to the early 1980s. Big Tobacco was was being pummelled by health authorities for lying about the health consequences of smoking, tobacco and nicotine. Many of these companies feared nicotine might get banned altogether in the US, so they set out to develop better alternatives to nicotine . Scientists at these companies created numerous different ‘nicotine-alternatives’ - some of which showed great promise, albiet less addictive.
Their fears never materialized, nicotine was not banned in the US, and Big Tobacco did their best to bury the evidence around these nicotine alternatives. We think they did so because they might have actually found compounds that are more effective than nicotine, but also likely less addictive.
Jumping back into today, scientists picked up where Big Tobacco left off. We identified the most promising of these nicotine alternatives then conducted our own clinical research to ensure safety and efficacy. Only then did we know this was the alternative product we wanted in SHGR snuff.
What we have now is a product that is perfectly tailored to the consumer that uses nicotine to be more productive and energized, but doesn’t want to be left feeling withdrawals or carrying vapes and pouches everywhere.
The Nixodine™ Science...
nAChr Activation Study
α4β2
Nicotinic α4β2 receptors have high affinity for nicotine and account for >90% of nicotine binding to brain tissue.

nAChr Activation Study
α3β4
Nicotinic α3β4 receptors are involved in nicotine reward and physical withdrawal.

nAChr Activation Study
α6/3/β2β3
Nicotinic α6/3/β2β3 receptors are involved in nicotine-stimulated dopamine release and may play a role in nicotine dependence.
